Adherence to recommendations and clinical outcomes of patients hospitalized for stroke: the role of the admission ward-a real-life investigation from Italy.
Identifieur interne : 000636 ( Main/Exploration ); précédent : 000635; suivant : 000637Adherence to recommendations and clinical outcomes of patients hospitalized for stroke: the role of the admission ward-a real-life investigation from Italy.
Auteurs : Federico Rea [Italie] ; Giuseppe Micieli [Italie] ; Massimo Musicco [Italie] ; Anna Cavallini [Italie] ; Claudia Santucci [Italie] ; Luca Merlino [Italie] ; Francesca Ieva [Italie] ; Carlo Ferrarese [Italie] ; Giovanni Corrao [Italie]Source :
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [ 1590-3478 ] ; 2019.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (thérapie), Accident vasculaire cérébral (épidémiologie), Admission du patient (MeSH), Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Encéphalopathie ischémique (thérapie), Encéphalopathie ischémique (épidémiologie), Femelle (MeSH), Guides de bonnes pratiques cliniques comme sujet (MeSH), Humains (MeSH), Hémorragie cérébrale (thérapie), Hémorragie cérébrale (épidémiologie), Italie (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Neurologie (MeSH), Observance par le patient (MeSH), Résultat thérapeutique (MeSH), Score de propension (MeSH), Spécialisation (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Études de cohortes (MeSH).
- MESH :
- thérapie : Accident vasculaire cérébral, Encéphalopathie ischémique, Hémorragie cérébrale.
- épidémiologie : Accident vasculaire cérébral, Encéphalopathie ischémique, Hémorragie cérébrale.
- Admission du patient, Adolescent, Adulte, Adulte d'âge moyen, Femelle, Guides de bonnes pratiques cliniques comme sujet, Humains, Italie, Jeune adulte, Mâle, Neurologie, Observance par le patient, Résultat thérapeutique, Score de propension, Spécialisation, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes.
- Wicri :
- geographic : Italie.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Brain Ischemia (epidemiology), Brain Ischemia (therapy), Cerebral Hemorrhage (epidemiology), Cerebral Hemorrhage (therapy), Cohort Studies (MeSH), Female (MeSH), Humans (MeSH), Italy (MeSH), Male (MeSH), Middle Aged (MeSH), Neurology (MeSH), Patient Admission (MeSH), Patient Compliance (MeSH), Practice Guidelines as Topic (MeSH), Propensity Score (MeSH), Specialization (MeSH), Stroke (epidemiology), Stroke (therapy), Treatment Outcome (MeSH), Young Adult (MeSH).
- MESH :
- geographic : Italy.
- epidemiology : Brain Ischemia, Cerebral Hemorrhage, Stroke.
- therapy : Brain Ischemia, Cerebral Hemorrhage, Stroke.
- Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Male, Middle Aged, Neurology, Patient Admission, Patient Compliance, Practice Guidelines as Topic, Propensity Score, Specialization, Treatment Outcome, Young Adult.
Abstract
OBJECTIVE
To determine whether out-of-hospital healthcare and adverse outcomes are better in stroke patients admitted to a neurology ward compared with those admitted to general wards.
METHODS
Beneficiaries of the National Health Service from the Italian Lombardy Region who were discharged alive after hospital admission during the year 2009 for ischemic stroke (9776 patients) or intracerebral or subarachnoid hemorrhage (1102 patients) entered into the cohort and were followed until 2012. Exposure of interest was the ward type where inpatients were admitted (neuro vs. general wards). Outcomes were out-of-hospital healthcare (i.e., drug prescriptions, diagnostic procedures, and laboratory clinical evaluations) and adverse clinical outcomes (i.e., all-cause death and hospital readmission). Exposure-outcome associations were investigated. High-dimensional propensity score methodology was used for taking into account confounders. Mediation analysis was used to verify whether the association between ward type and clinical outcomes is mediated by out-of-hospital adherence to healthcare.
RESULTS
Better adherence to out-of-hospital healthcare received from patients discharged from neuro, rather than general, wards was observed being the proportions of adherent patients 42.4% and 39.5%, respectively. Compared with general wards, discharge from neuro was associated with reduced 3-year emergency admissions (from 50.1 to 47.5% among ischemic stroke patients) and reduced 3-year mortality (from 37.5 to 27.0% among hemorrhagic stroke patients). From 10 to 15% of outcome risk, reductions were mediated by better adherence to out-of-hospital healthcare.
CONCLUSIONS
For patients with acute ischemic and hemorrhagic stroke, admission to neuro vs. general wards is associated with better out-of-hospital healthcare and long-term adverse outcomes.
DOI: 10.1007/s10072-019-03867-7
PubMed: 30941626
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Musicco, Massimo" sort="Musicco, Massimo" uniqKey="Musicco M" first="Massimo" last="Musicco">Massimo Musicco</name><affiliation wicri:level="3"><nlm:affiliation>National Research Council of Italy, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>National Research Council of Italy, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Cavallini, Anna" sort="Cavallini, Anna" uniqKey="Cavallini A" first="Anna" last="Cavallini">Anna Cavallini</name><affiliation wicri:level="1"><nlm:affiliation>San Matteo Hospital Stroke Unit and Mondino Institute Cerebrovascular Disease and Stroke Unit, IRCCS Mondino Foundation, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Matteo Hospital Stroke Unit and 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last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, San Gerardo Hospital, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMi), University of Milano-Bicocca, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMi), University of Milano-Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Corrao, Giovanni" sort="Corrao, Giovanni" uniqKey="Corrao G" first="Giovanni" last="Corrao">Giovanni Corrao</name><affiliation wicri:level="3"><nlm:affiliation>National Centre for Healthcare Research & 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wicri:level="3"><nlm:affiliation>National Centre for Healthcare Research & Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy. f.rea@campus.unimib.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>National Centre for Healthcare Research & Pharmacoepidemiology, University of Milano-Bicocca, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy. f.rea@campus.unimib.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Micieli, Giuseppe" sort="Micieli, Giuseppe" uniqKey="Micieli G" first="Giuseppe" last="Micieli">Giuseppe Micieli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Emergency Neurology, IRCCS Mondino Foundation, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Emergency Neurology, IRCCS Mondino Foundation, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Musicco, Massimo" sort="Musicco, Massimo" uniqKey="Musicco M" first="Massimo" last="Musicco">Massimo Musicco</name><affiliation wicri:level="3"><nlm:affiliation>National Research Council of Italy, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>National Research Council of Italy, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Cavallini, Anna" sort="Cavallini, Anna" uniqKey="Cavallini A" first="Anna" last="Cavallini">Anna Cavallini</name><affiliation wicri:level="1"><nlm:affiliation>San Matteo Hospital Stroke Unit and Mondino Institute Cerebrovascular Disease and Stroke Unit, IRCCS Mondino Foundation, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Matteo Hospital Stroke Unit and Mondino Institute Cerebrovascular Disease and Stroke Unit, IRCCS Mondino Foundation, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Santucci, Claudia" sort="Santucci, Claudia" uniqKey="Santucci C" first="Claudia" last="Santucci">Claudia Santucci</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Merlino, Luca" sort="Merlino, Luca" uniqKey="Merlino L" first="Luca" last="Merlino">Luca Merlino</name><affiliation wicri:level="3"><nlm:affiliation>Epidemiologic Observatory, Lombardy Regional Health Service, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiologic Observatory, Lombardy Regional Health Service, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Ieva, Francesca" sort="Ieva, Francesca" uniqKey="Ieva F" first="Francesca" last="Ieva">Francesca Ieva</name><affiliation wicri:level="3"><nlm:affiliation>MOX-Modelling and Scientific Computing, Department of Mathematics, Politecnico di Milano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MOX-Modelling and Scientific Computing, Department of Mathematics, Politecnico di Milano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, San Gerardo Hospital, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMi), University of Milano-Bicocca, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMi), University of Milano-Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Corrao, Giovanni" sort="Corrao, Giovanni" uniqKey="Corrao G" first="Giovanni" last="Corrao">Giovanni Corrao</name><affiliation wicri:level="3"><nlm:affiliation>National Centre for Healthcare Research & Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>National Centre for Healthcare Research & Pharmacoepidemiology, University of Milano-Bicocca, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><series><title level="j">Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology</title><idno type="eISSN">1590-3478</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Brain Ischemia (epidemiology)</term><term>Brain Ischemia (therapy)</term><term>Cerebral Hemorrhage (epidemiology)</term><term>Cerebral Hemorrhage (therapy)</term><term>Cohort Studies (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Italy (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Neurology (MeSH)</term><term>Patient Admission (MeSH)</term><term>Patient Compliance (MeSH)</term><term>Practice Guidelines as Topic (MeSH)</term><term>Propensity Score (MeSH)</term><term>Specialization (MeSH)</term><term>Stroke (epidemiology)</term><term>Stroke (therapy)</term><term>Treatment Outcome (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (thérapie)</term><term>Accident vasculaire cérébral (épidémiologie)</term><term>Admission du patient (MeSH)</term><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Encéphalopathie ischémique (thérapie)</term><term>Encéphalopathie ischémique (épidémiologie)</term><term>Femelle (MeSH)</term><term>Guides de bonnes pratiques cliniques comme sujet (MeSH)</term><term>Humains (MeSH)</term><term>Hémorragie cérébrale (thérapie)</term><term>Hémorragie cérébrale (épidémiologie)</term><term>Italie (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Neurologie (MeSH)</term><term>Observance par le patient (MeSH)</term><term>Résultat thérapeutique (MeSH)</term><term>Score de propension (MeSH)</term><term>Spécialisation (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Études de cohortes (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Italy</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Brain Ischemia</term><term>Cerebral Hemorrhage</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Brain Ischemia</term><term>Cerebral Hemorrhage</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Encéphalopathie ischémique</term><term>Hémorragie cérébrale</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Encéphalopathie ischémique</term><term>Hémorragie cérébrale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurology</term><term>Patient Admission</term><term>Patient Compliance</term><term>Practice Guidelines as Topic</term><term>Propensity Score</term><term>Specialization</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Admission du patient</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Italie</term><term>Jeune adulte</term><term>Mâle</term><term>Neurologie</term><term>Observance par le patient</term><term>Résultat thérapeutique</term><term>Score de propension</term><term>Spécialisation</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études de cohortes</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Italie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To determine whether out-of-hospital healthcare and adverse outcomes are better in stroke patients admitted to a neurology ward compared with those admitted to general wards.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Beneficiaries of the National Health Service from the Italian Lombardy Region who were discharged alive after hospital admission during the year 2009 for ischemic stroke (9776 patients) or intracerebral or subarachnoid hemorrhage (1102 patients) entered into the cohort and were followed until 2012. Exposure of interest was the ward type where inpatients were admitted (neuro vs. general wards). Outcomes were out-of-hospital healthcare (i.e., drug prescriptions, diagnostic procedures, and laboratory clinical evaluations) and adverse clinical outcomes (i.e., all-cause death and hospital readmission). Exposure-outcome associations were investigated. High-dimensional propensity score methodology was used for taking into account confounders. Mediation analysis was used to verify whether the association between ward type and clinical outcomes is mediated by out-of-hospital adherence to healthcare.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Better adherence to out-of-hospital healthcare received from patients discharged from neuro, rather than general, wards was observed being the proportions of adherent patients 42.4% and 39.5%, respectively. Compared with general wards, discharge from neuro was associated with reduced 3-year emergency admissions (from 50.1 to 47.5% among ischemic stroke patients) and reduced 3-year mortality (from 37.5 to 27.0% among hemorrhagic stroke patients). From 10 to 15% of outcome risk, reductions were mediated by better adherence to out-of-hospital healthcare.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>For patients with acute ischemic and hemorrhagic stroke, admission to neuro vs. general wards is associated with better out-of-hospital healthcare and long-term adverse outcomes.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30941626</PMID><DateCompleted><Year>2020</Year><Month>01</Month><Day>13</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1590-3478</ISSN><JournalIssue CitedMedium="Internet"><Volume>40</Volume><Issue>7</Issue><PubDate><Year>2019</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology</Title><ISOAbbreviation>Neurol Sci</ISOAbbreviation></Journal><ArticleTitle>Adherence to recommendations and clinical outcomes of patients hospitalized for stroke: the role of the admission ward-a real-life investigation from Italy.</ArticleTitle><Pagination><MedlinePgn>1433-1442</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10072-019-03867-7</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine whether out-of-hospital healthcare and adverse outcomes are better in stroke patients admitted to a neurology ward compared with those admitted to general wards.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Beneficiaries of the National Health Service from the Italian Lombardy Region who were discharged alive after hospital admission during the year 2009 for ischemic stroke (9776 patients) or intracerebral or subarachnoid hemorrhage (1102 patients) entered into the cohort and were followed until 2012. Exposure of interest was the ward type where inpatients were admitted (neuro vs. general wards). Outcomes were out-of-hospital healthcare (i.e., drug prescriptions, diagnostic procedures, and laboratory clinical evaluations) and adverse clinical outcomes (i.e., all-cause death and hospital readmission). Exposure-outcome associations were investigated. High-dimensional propensity score methodology was used for taking into account confounders. Mediation analysis was used to verify whether the association between ward type and clinical outcomes is mediated by out-of-hospital adherence to healthcare.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Better adherence to out-of-hospital healthcare received from patients discharged from neuro, rather than general, wards was observed being the proportions of adherent patients 42.4% and 39.5%, respectively. Compared with general wards, discharge from neuro was associated with reduced 3-year emergency admissions (from 50.1 to 47.5% among ischemic stroke patients) and reduced 3-year mortality (from 37.5 to 27.0% among hemorrhagic stroke patients). From 10 to 15% of outcome risk, reductions were mediated by better adherence to out-of-hospital healthcare.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">For patients with acute ischemic and hemorrhagic stroke, admission to neuro vs. general wards is associated with better out-of-hospital healthcare and long-term adverse outcomes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rea</LastName><ForeName>Federico</ForeName><Initials>F</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-7988-5101</Identifier><AffiliationInfo><Affiliation>National Centre for Healthcare Research & Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy. f.rea@campus.unimib.it.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy. f.rea@campus.unimib.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Micieli</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Emergency Neurology, IRCCS Mondino Foundation, Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Musicco</LastName><ForeName>Massimo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National Research Council of Italy, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cavallini</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>San Matteo Hospital Stroke Unit and Mondino Institute Cerebrovascular Disease and Stroke Unit, IRCCS Mondino Foundation, Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Santucci</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merlino</LastName><ForeName>Luca</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Epidemiologic Observatory, Lombardy Regional Health Service, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ieva</LastName><ForeName>Francesca</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>MOX-Modelling and Scientific Computing, Department of Mathematics, Politecnico di Milano, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferrarese</LastName><ForeName>Carlo</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, San Gerardo Hospital, Monza, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMi), University of Milano-Bicocca, Monza, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corrao</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>National Centre for Healthcare Research & Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>2017-COMM25-0086</GrantID><Agency>Italian Society of Neurology</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>04</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Neurol Sci</MedlineTA><NlmUniqueID>100959175</NlmUniqueID><ISSNLinking>1590-1874</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002545" MajorTopicYN="N">Brain Ischemia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002543" MajorTopicYN="N">Cerebral Hemorrhage</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009462" MajorTopicYN="N">Neurology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010343" MajorTopicYN="Y">Patient Admission</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010349" MajorTopicYN="Y">Patient Compliance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017410" MajorTopicYN="N">Practice Guidelines as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057216" MajorTopicYN="N">Propensity Score</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013038" MajorTopicYN="N">Specialization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020521" MajorTopicYN="N">Stroke</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Healthcare utilization database</Keyword><Keyword MajorTopicYN="N">Intracerebral or subarachnoid hemorrhage</Keyword><Keyword MajorTopicYN="N">Ischemic stroke</Keyword><Keyword MajorTopicYN="N">Mortality</Keyword><Keyword MajorTopicYN="N">Neurology wards</Keyword><Keyword MajorTopicYN="N">Population-based cohort study</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>10</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>03</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>4</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>1</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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IdType="pubmed">30009334</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Latium</li><li>Lombardie</li></region><settlement><li>Milan</li><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Rea, Federico" sort="Rea, Federico" uniqKey="Rea F" first="Federico" last="Rea">Federico Rea</name></region><name sortKey="Cavallini, Anna" sort="Cavallini, Anna" uniqKey="Cavallini A" first="Anna" last="Cavallini">Anna Cavallini</name><name sortKey="Corrao, Giovanni" sort="Corrao, Giovanni" uniqKey="Corrao G" first="Giovanni" last="Corrao">Giovanni Corrao</name><name sortKey="Corrao, Giovanni" sort="Corrao, Giovanni" uniqKey="Corrao G" first="Giovanni" last="Corrao">Giovanni Corrao</name><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><name sortKey="Ieva, Francesca" sort="Ieva, Francesca" uniqKey="Ieva F" first="Francesca" last="Ieva">Francesca Ieva</name><name sortKey="Merlino, Luca" sort="Merlino, Luca" uniqKey="Merlino L" first="Luca" last="Merlino">Luca Merlino</name><name sortKey="Micieli, Giuseppe" sort="Micieli, Giuseppe" uniqKey="Micieli G" first="Giuseppe" last="Micieli">Giuseppe Micieli</name><name sortKey="Musicco, Massimo" sort="Musicco, Massimo" uniqKey="Musicco M" first="Massimo" last="Musicco">Massimo Musicco</name><name sortKey="Rea, Federico" sort="Rea, Federico" uniqKey="Rea F" first="Federico" last="Rea">Federico Rea</name><name sortKey="Santucci, Claudia" sort="Santucci, Claudia" uniqKey="Santucci C" first="Claudia" last="Santucci">Claudia Santucci</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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